Have you tried to disable USB access by modifying the Registry service for UsbStor. You could make a simple batch file and run it from there.
simply open notepad or similar text editor and save the file with FILENAME.bat
copy paste the following in the text file:
reg add HKLM\SYSTEM\CurrentControlSet\Services\UsbStor /v “Start” /t REG_DWORD /d “4” /f
(to re enable it substitute the 4 at the end to a 3)
reg add HKLM\SYSTEM\CurrentControlSet\Services\UsbStor /v “Start” /t REG_DWORD /d “3” /f
You can get even more details form the following link the stackoverflow community.